KLHL35

Across TCGA patient cohorts, KLHL35 mutation is significantly associated with the RNA expression of many other genes, with 459 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL35-associated genes across cancer lineages are SYPL1P1, PABPC1L2B-AS1, and DUXAP3. Each is linked with KLHL35 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL35-to-partner and partner-to-KLHL35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYPL1P1 grouped by KLHL35-low versus KLHL35-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL35→partner) and Y-score (partner→KLHL35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SYPL1P1 →	+0.106	+4.894	<.001	.004	3	2
UCEC	PABPC1L2B-AS1 →	+0.011	+3.923	<.001	.009	3	2
LIHC	DUXAP3 →	+0.056	+4.564	<.001	.006	3	1
LIHC	OOEPP1 →	+0.141	+4.413	<.001	.002	3	1
LIHC	IGLCOR22-2 →	+0.207	+4.940	<.001	<.001	3	1
LIHC	RNU7-10P →	+0.664	+4.547	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 459 associations by consensus.

SYPL1P1 by KLHL35 expression — LIHC

Explore this box plot interactively →