KLHL35

Across TCGA pan-cancer cohorts, KLHL35 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KLHL35 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLHL35 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL35 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and LGG are the cancer types where KLHL35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.754	0.551	.002	64	view →
LUAD	OS	Tertile	All	0.862	0.696	.001	62	view →
LGG	DFS	Median	All	0.821	0.657	<.001	53	view →
UVM	DFS	Median	All	0.733	0.413	<.001	51	view →
ACC	DFS	Tertile	All	0.124	0.643	.002	47	view →
LIHC	OS	Tertile	III,IV	0.377	0.628	.002	30	view →
READ	DFS	Tertile	III,IV	0.671	0.361	.004	30	view →
SKCM	OS	Tertile	II,III,IV	0.215	0.369	.014	26	view →
CESC	DFS	Tertile	All	0.640	0.354	.005	24	view →
MESO	OS	Median	II,III,IV	0.768	0.277	.001	24	view →
SARC	OS	Median	All	0.670	0.814	<.001	21	view →
ESCA	DFS	Quartile	All	0.423	0.674	.003	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

KLHL35–HNSC (DFS)

Open the HNSC breakdown →