KLHL29

Across TCGA cell cohorts, KLHL29 mutation is significantly associated with the RNA expression of many other genes, with 661 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL29-associated genes across cancer lineages are TPPP2, RBMY1J, and PSMG2. Each is linked with KLHL29 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL29-to-partner and partner-to-KLHL29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPPP2 grouped by KLHL29-low versus KLHL29-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL29→partner) and Y-score (partner→KLHL29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TPPP2 →	+0.111	+3.657	<.001	.009	3	2
OVARY	RBMY1J →	+0.014	+4.222	<.001	.006	3	2
LARGE_INTESTINE	PSMG2 →	+0.566	+2.451	<.001	.009	3	2
BREAST	OR4E1 →	+0.090	+4.196	<.001	.006	3	2
OVARY	GPR6 →	+0.013	+4.222	<.001	.006	3	1
OVARY	OR13C4 →	+0.022	+3.990	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 661 associations by consensus.

TPPP2 by KLHL29 expression — OVARY

Explore this box plot interactively →