KLHL29

Across TCGA pan-cancer cohorts, KLHL29 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated KLHL29 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KLHL29 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL29 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCS show a favorable association.

COAD, UCS, and LGG are the cancer types where KLHL29 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.542	0.278	<.001	73	view →
UCS	OS	Median	III,IV	0.647	0.218	<.001	60	view →
LGG	OS	Median	All	0.731	0.886	<.001	43	view →
KIRP	DFS	Quartile	All	0.736	0.915	.002	41	view →
MESO	OS	Tertile	All	0.483	0.685	.009	35	view →
LIHC	OS	Quartile	All	0.586	0.785	.001	34	view →
THCA	DFS	Tertile	II,III,IV	0.503	0.872	.003	31	view →
PAAD	OS	Quartile	All	0.770	0.433	.002	23	view →
BLCA	OS	Median	II,III,IV	0.766	0.667	.008	21	view →
KIRC	DFS	Tertile	II,III,IV	0.621	0.787	.017	19	view →
ESCA	OS	Median	II,III,IV	0.640	0.425	.006	18	view →
ACC	OS	Median	IV	0.908	0.523	.013	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

KLHL29–COAD (DFS)

Open the COAD breakdown →