KLHL25

Across TCGA patient cohorts, KLHL25 mutation is significantly associated with the RNA expression of many other genes, with 3,092 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL25-associated genes across cancer lineages are AQP7P4, FAM197Y7, and KATNBL1P4. Each is linked with KLHL25 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL25-to-partner and partner-to-KLHL25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P4 grouped by KLHL25-low versus KLHL25-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL25→partner) and Y-score (partner→KLHL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AQP7P4 →	+0.035	+4.526	<.001	.007	3	3
HNSC	FAM197Y7 →	+0.679	+4.754	<.001	.005	3	2
BLCA	KATNBL1P4 →	+0.065	+6.018	.003	.002	3	2
SKCM	GAGE12H →	+0.331	+3.508	.004	.006	3	2
UCEC	MMP12 →	+0.880	+1.773	.005	.008	3	2
BLCA	RN7SL237P →	+0.302	+4.973	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,092 associations by consensus.

AQP7P4 by KLHL25 expression — HNSC

Explore this box plot interactively →