KLHL25

Across TCGA pan-cancer cohorts, KLHL25 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KLHL25 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher KLHL25 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHL25 expression acts as an unfavorable survival marker, although some lineages such as LGG and SCLC show a favorable association.

LIHC, LGG, and ACC are the cancer types where KLHL25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.464	0.617	<.001	55	view →
LGG	DFS	Median	All	0.493	0.303	<.001	50	view →
ACC	DFS	Median	All	0.400	0.750	<.001	46	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	45	view →
LUAD	DFS	Median	II,III,IV	0.595	0.768	.001	40	view →
ESCA	OS	Median	II,III,IV	0.622	0.784	.015	25	view →
SCLC	OS	Median	All	0.805	0.600	.005	18	view →
OV	DFS	Quartile	II,III,IV	0.593	0.476	.009	18	view →
THYM	OS	Tertile	II,III,IV	1.000	0.696	.006	16	view →
PAAD	DFS	Quartile	II,III,IV	0.511	0.270	.007	16	view →
UCS	OS	Quartile	All	0.729	0.341	.018	14	view →
SKCM	OS	Tertile	II,III,IV	0.280	0.507	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KLHL25–LIHC (DFS)

Open the LIHC breakdown →