KLHL24

Across TCGA patient cohorts, KLHL24 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL24-associated genes across cancer lineages are 4E-BP1_pT70, FoxM1, and mTOR_pS2448. Each is linked with KLHL24 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL24-to-partner and partner-to-KLHL24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by KLHL24-low versus KLHL24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL24→partner) and Y-score (partner→KLHL24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT70 →	+0.093	+2.459	.014	.018	3	3
UCEC	FoxM1 →	+0.204	+1.652	.016	.006	3	2
UCEC	mTOR_pS2448 →	-0.145	-2.565	.003	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.780	+2.604	<.001	<.001	3	2
UCEC	Collagen-VI →	-0.158	-2.102	.020	.016	3	2
UCEC	14-3-3_beta →	-0.079	-2.088	.016	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

4E-BP1_pT70 by KLHL24 expression — UCEC

Explore this box plot interactively →