KLHL24

Across TCGA pan-cancer cohorts, KLHL24 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated KLHL24 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KLHL24 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KLHL24 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

KIRC, ACC, and STAD are the cancer types where KLHL24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.731	0.582	<.001	71	view →
ACC	OS	Median	II,III,IV	0.933	0.767	.001	44	view →
STAD	DFS	Quartile	II,III,IV	0.281	0.633	.010	23	view →
UCEC	DFS	Quartile	All	0.496	0.720	<.001	20	view →
LUAD	DFS	Tertile	II,III,IV	0.568	0.283	.019	19	view →
LUSC	DFS	Tertile	All	0.860	0.585	.002	18	view →
ESCA	OS	Tertile	IV	0.219	0.856	.024	18	view →
LAML	DFS	Quartile	All	0.546	0.347	.021	16	view →
CESC	OS	Quartile	All	0.961	0.830	.002	14	view →
HNSC	OS	Quartile	All	0.598	0.799	.008	13	view →
READ	DFS	Quartile	IV	0.414	0.877	.013	13	view →
GBM	OS	Tertile	All	0.619	0.337	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

KLHL24–KIRC (OS)

Open the KIRC breakdown →