KLHL24

Across TCGA pan-cancer cohorts, KLHL24 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KLHL24’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLHL24 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHL24 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, KIRP, and THCA are the cancer types where KLHL24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.938	.003	8	view →
KIRP	All	All	+0.412	.006	7	view →
THCA	All	All	−0.466	<.001	6	view →
CHOL	All	All	+1.342	<.001	5	view →
LUSC	All	All	+0.698	<.001	5	view →
BLCA	All	All	+0.636	.013	5	view →
LUAD	Female	II,III,IV	−0.635	.001	4	view →
BRCA	Female	All	−0.258	.001	4	view →
LIHC	All	All	+0.415	.001	3	view →
PAAD	Female	All	−0.314	.007	2	view →
KIRC	Female	III,IV	+0.488	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KLHL24–HNSC

Open the HNSC breakdown →