KLHL23

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, KLHL23 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible KLHL23-associated genes across cancer lineages are ACTRT1, ADAM7, and TFDP3. Each is linked with KLHL23 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL23-to-partner and partner-to-KLHL23 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL23→partner) and Y-score (partner→KLHL23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLOOD_LeukemiaACTRT1 →+0.021+5.201<.001.00632
BLOOD_LeukemiaADAM7 →+0.021+4.922.001.00932
LARGE_INTESTINETFDP3 →+0.021+2.518<.001.00632
UPPER_AERODIGESTIVE_TRACTKNCN →+0.023+4.736<.001.00932
UPPER_AERODIGESTIVE_TRACTTFAP2D →+0.077+4.736<.001.00932
BLOOD_LymphomaKRTAP9-1 →+0.053+6.247<.001<.00131
Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Exploration