KLHL22

Across TCGA patient cohorts, KLHL22 mutation is significantly associated with the RNA expression of many other genes, with 3,370 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL22-associated genes across cancer lineages are LACTB, TSPY26P, and RPL23AP82. Each is linked with KLHL22 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL22-to-partner and partner-to-KLHL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LACTB grouped by KLHL22-low versus KLHL22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL22→partner) and Y-score (partner→KLHL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LACTB →	+0.545	+3.839	<.001	<.001	3	4
SKCM	TSPY26P →	-0.954	-2.980	.002	.001	3	4
UCEC	RPL23AP82 →	+0.315	+3.592	.005	.001	3	3
UCEC	EMID1 →	-1.364	-3.574	<.001	.002	3	3
UCEC	TAF13 →	+0.616	+3.711	<.001	<.001	3	3
UCEC	RANP5 →	+0.184	+1.549	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,370 associations by consensus.

LACTB by KLHL22 expression — UCEC

Explore this box plot interactively →