KLHL22

Across TCGA pan-cancer cohorts, KLHL22 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KLHL22 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KLHL22 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL22 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PAAD show a favorable association.

UCEC, UVM, and ACC are the cancer types where KLHL22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.892	0.668	<.001	98	view →
UVM	DFS	Tertile	II,III,IV	0.399	0.870	<.001	74	view →
ACC	DFS	Median	All	0.187	0.656	<.001	71	view →
PAAD	OS	Median	All	0.544	0.265	<.001	55	view →
LIHC	DFS	Median	All	0.474	0.609	.001	52	view →
KIRP	DFS	Quartile	II,III,IV	0.940	0.141	.005	45	view →
KIRC	OS	Median	All	0.713	0.557	<.001	29	view →
COAD	DFS	Tertile	II,III,IV	0.370	0.745	.002	25	view →
SCLC	OS	Median	II,III,IV	1.000	0.421	.002	18	view →
LUSC	DFS	Median	III,IV	0.509	0.916	.006	14	view →
HNSC	DFS	Median	All	0.767	0.651	.002	14	view →
THCA	DFS	Median	All	0.964	0.904	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

KLHL22–UCEC (DFS)

Open the UCEC breakdown →