KLHL20

Across TCGA cell cohorts, KLHL20 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL20-associated genes across cancer lineages are KLHL40, RNASE8, and SIAH3. Each is linked with KLHL20 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL20-to-partner and partner-to-KLHL20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by KLHL20-low versus KLHL20-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL20→partner) and Y-score (partner→KLHL20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	RNASE8 →	+0.044	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	SIAH3 →	+0.042	+4.867	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	NPHS2 →	+0.013	+4.736	<.001	.009	3	1
BLOOD_Leukemia	OR6M1 →	+0.024	+4.539	<.001	.007	3	1
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KLHL40 by KLHL20 expression — BLOOD_Lymphoma

Explore this box plot interactively →