KLHL20

Across TCGA pan-cancer cohorts, KLHL20 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KLHL20’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLHL20 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHL20 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where KLHL20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.548	<.001	10	view →
KIRC	Male	All	+0.487	<.001	10	view →
KICH	Female	All	−1.232	<.001	7	view →
LIHC	All	All	+0.536	<.001	3	view →
THCA	All	All	−0.308	.012	3	view →
CHOL	All	All	+1.105	.004	2	view →
UCEC	All	All	−0.889	<.001	2	view →
PAAD	Male	All	+0.285	.011	2	view →
BRCA	All	All	−0.196	.002	2	view →
READ	Female	All	−0.713	.048	1	view →
ESCA	All	All	+0.447	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KLHL20–HNSC

Open the HNSC breakdown →