KLHL13

Across TCGA patient cohorts, KLHL13 protein abundance is significantly associated with the protein abundance of many other proteins, with 12,400 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KLHL13-associated proteins across cancer lineages are FCHSD2_S644, CTSV, and DGKH. Each is linked with KLHL13 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL13-to-partner and partner-to-KLHL13 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL13 versus FCHSD2_S644 in PDAC, with a Pearson correlation of 0.53.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL13→partner) and Y-score (partner→KLHL13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FCHSD2_S644 →	+0.653	+1.049	<.001	<.001	3	3
UCEC	CTSV →	+0.764	+0.444	<.001	<.001	3	2
LSCC	DGKH →	+0.435	+0.563	<.001	<.001	3	2
HNSC	FAM234A →	+1.178	+0.920	<.001	<.001	3	2
PDAC	SPTA1_S510 →	+1.983	+2.000	<.001	<.001	3	2
BRCA	LAT_S224 →	+1.211	+0.988	.001	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,400 associations by consensus.

KLHL13 vs FCHSD2_S644 — PDAC

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