KLHL10

Across TCGA cell cohorts, KLHL10 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL10-associated genes across cancer lineages are SPINK14, IZUMO1R, and GPR171. Each is linked with KLHL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL10-to-partner and partner-to-KLHL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK14 grouped by KLHL10-low versus KLHL10-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL10→partner) and Y-score (partner→KLHL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINK14 →	+0.264	+4.662	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
LARGE_INTESTINE	GPR171 →	+0.019	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CFHR2 →	+0.057	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SPINK14 by KLHL10 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →