KLHL10

Across TCGA pan-cancer cohorts, KLHL10 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLHL10’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KLHL10 RNA is repressed in tumor relative to normal tissue. In most cancer types KLHL10 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and BRCA are the cancer types where KLHL10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−0.530	<.001	11	view →
THCA	Male	III,IV	−0.605	<.001	10	view →
BRCA	All	III,IV	−0.327	<.001	8	view →
LUAD	Female	II,III,IV	−0.138	<.001	7	view →
UCEC	All	All	−0.489	<.001	6	view →
STAD	All	All	−0.327	<.001	5	view →
KICH	All	All	−0.154	<.001	5	view →
LUSC	Male	All	−0.109	<.001	5	view →
COAD	Male	All	−0.174	.006	4	view →
LIHC	All	All	+0.043	.005	4	view →
READ	All	III,IV	−0.329	.011	3	view →
PRAD	All	All	−0.263	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KLHL10–BLCA

Open the BLCA breakdown →