KLHDC4

Across TCGA cell cohorts, KLHDC4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHDC4-associated genes across cancer lineages are IFNG, GSTA3, and MAGEB10. Each is linked with KLHDC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHDC4-to-partner and partner-to-KLHDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNG grouped by KLHDC4-low versus KLHDC4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHDC4→partner) and Y-score (partner→KLHDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNG →	+0.149	+3.567	<.001	.003	3	1
BLOOD_Leukemia	GSTA3 →	+0.009	+3.969	.002	.009	3	1
LUNG_NSCLC_LUAD	MAGEB10 →	+0.021	+4.544	.002	.003	3	1
LUNG_NSCLC_LUAD	PRAMEF19 →	+0.012	+4.662	<.001	.005	3	1
STOMACH	ANKRD60 →	+0.030	+5.285	<.001	.003	3	1
LARGE_INTESTINE	OR2C1 →	+0.191	+3.725	<.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

IFNG by KLHDC4 expression — BLOOD_Leukemia

Explore this box plot interactively →