KLHDC4

Across TCGA pan-cancer cohorts, KLHDC4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLHDC4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KLHDC4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHDC4 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where KLHDC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHDC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.636	<.001	12	view →
KIRP	All	II,III,IV	+0.578	<.001	11	view →
COAD	Female	All	+0.958	<.001	10	view →
STAD	Male	II,III,IV	+1.102	<.001	9	view →
LIHC	Female	II,III,IV	+0.909	<.001	9	view →
HNSC	Male	III,IV	+0.554	<.001	8	view →
CHOL	All	All	+1.907	<.001	5	view →
BLCA	All	All	+0.348	.011	5	view →
BRCA	Female	All	−0.228	.002	4	view →
READ	All	III,IV	+0.640	.002	3	view →
LUAD	All	All	+0.185	.013	2	view →
ESCA	All	All	+0.549	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KLHDC4–KIRC

Open the KIRC breakdown →