KLF7

Across TCGA patient cohorts, KLF7 mutation is significantly associated with the RNA expression of many other genes, with 2,451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF7-associated genes across cancer lineages are CRYBB2P1, WDR59, and CSK. Each is linked with KLF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF7-to-partner and partner-to-KLF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB2P1 grouped by KLF7-low versus KLF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF7→partner) and Y-score (partner→KLF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CRYBB2P1 →	+0.426	+1.665	<.001	.002	3	2
UCEC	WDR59 →	+0.338	+2.478	<.001	.001	3	2
UCEC	CSK →	+0.342	+2.457	.001	.001	3	2
UCEC	LIG1 →	+0.399	+1.447	.002	.006	3	2
UCEC	BCCIP →	+0.320	+2.633	.006	<.001	3	2
UCEC	GIT1 →	+0.358	+1.903	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,451 associations by consensus.

CRYBB2P1 by KLF7 expression — UCEC

Explore this box plot interactively →