KLF7

Across TCGA pan-cancer cohorts, KLF7 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated KLF7 data layer compared with 7 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher KLF7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KLF7 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

MESO, KIRC, and KIRP are the cancer types where KLF7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.446	0.633	.001	111	view →
KIRC	OS	Median	All	0.725	0.538	<.001	80	view →
KIRP	OS	Quartile	All	0.599	0.816	.001	58	view →
CESC	DFS	Tertile	All	0.446	0.749	<.001	54	view →
HNSC	OS	Median	All	0.698	0.806	<.001	52	view →
SCLC	DFS	Tertile	III,IV	0.768	0.243	.001	42	view →
LGG	OS	Median	All	0.757	0.866	<.001	37	view →
PAAD	DFS	Median	All	0.179	0.369	.010	35	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	34	view →
STAD	OS	Median	II,III,IV	0.454	0.661	.003	26	view →
UCS	DFS	Tertile	IV	0.942	0.403	.024	26	view →
ESCA	OS	Tertile	All	1.000	0.546	.014	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

KLF7–MESO (OS)

Open the MESO breakdown →