KLF7

Across TCGA pan-cancer cohorts, KLF7 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KLF7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLF7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLF7 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and UCEC are the cancer types where KLF7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.208	<.001	12	view →
KIRC	Female	All	+0.798	<.001	8	view →
UCEC	All	All	−1.725	<.001	6	view →
BRCA	Female	All	−0.642	<.001	6	view →
CHOL	Male	All	+2.235	<.001	4	view →
COAD	All	All	+0.576	.008	3	view →
READ	All	III,IV	+1.085	.031	2	view →
LUAD	Female	All	−0.466	.002	2	view →
THCA	All	All	−0.334	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

KLF7–HNSC

Open the HNSC breakdown →