KLF7

Across TCGA patient cohorts, KLF7 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF7-associated genes across cancer lineages are eIF4E, FoxM1, and TFRC. Each is linked with KLF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF7-to-partner and partner-to-KLF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KLF7-low versus KLF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF7→partner) and Y-score (partner→KLF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.202	+3.820	.004	<.001	3	2
UCEC	FoxM1 →	+0.228	+1.584	.008	.009	3	2
UCEC	TFRC →	+0.567	+2.415	.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.189	-1.700	.024	.040	3	1
UCEC	FASN →	+0.359	+1.584	.006	.009	3	1
UCEC	ACC_pS79 →	+0.307	+1.331	.008	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by KLF7 expression — UCEC

Explore this box plot interactively →