KLF7

Across TCGA cell cohorts, KLF7 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. CNS shows the largest number of these associations.

The most reproducible KLF7-associated genes across cancer lineages are CD1B, OR10K2, and PRAMEF10. Each is linked with KLF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF7-to-partner and partner-to-KLF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD1B grouped by KLF7-low versus KLF7-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF7→partner) and Y-score (partner→KLF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CD1B →	+0.287	+3.523	<.001	.008	3	1
LUNG_SCLC	OR10K2 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	IZUMO3 →	+0.473	+4.256	<.001	.002	3	1
CNS	F9 →	+0.021	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

CD1B by KLF7 expression — LUNG_SCLC

Explore this box plot interactively →