KLF3-AS1

Across TCGA pan-cancer cohorts, KLF3-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated KLF3-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher KLF3-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KLF3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

BLCA, HNSC, and LGG are the cancer types where KLF3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	All	0.598	0.415	.001	68	view →
HNSC	OS	Tertile	All	0.851	0.700	.001	53	view →
LGG	DFS	Median	All	0.780	0.881	<.001	45	view →
ACC	DFS	Median	All	0.240	0.649	<.001	43	view →
BRCA	OS	Median	III,IV	0.957	0.844	.001	39	view →
PAAD	OS	Median	II,III,IV	0.469	0.275	.008	35	view →
SKCM	DFS	Quartile	All	0.655	0.517	.003	22	view →
MESO	OS	Tertile	All	0.463	0.215	.002	18	view →
READ	OS	Quartile	All	0.980	0.845	.009	17	view →
ESCA	OS	Median	IV	0.222	0.698	.006	15	view →
UCS	DFS	Tertile	IV	0.975	0.361	.024	12	view →
LUAD	DFS	Tertile	IV	0.290	0.896	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

KLF3-AS1–BLCA (DFS)

Open the BLCA breakdown →