Q-omics provides the consensus-scored KLF3-AS1 profile across patient tissues and cancer cell-line models. KLF3-AS1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, KLF3-AS1 is differentially expressed in 11, with the highest sampling consensus in UCEC. Additionally, KLF3-AS1 RNA expression shows 20,055 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight BLCA, UCEC, and THYM as cancer lineages where KLF3-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KLF3-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KLF3-AS1 survival associations across molecular data types. KLF3-AS1 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KLF3-AS1 RNA expression–survival associations across cancer types. High KLF3-AS1 expression shows unfavorable associations in LGG and ACC, but favorable associations in BLCA, HNSC, BRCA and PAAD. The BLCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify BLCA as the clearest survival context for KLF3-AS1 RNA expression.
This table summarizes KLF3-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for KLF3-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KLF3-AS1 shows lower tumor expression in UCEC, BRCA, LUSC, KICH and HNSC and higher tumor expression in LIHC. The UCEC box plot shows higher KLF3-AS1 RNA expression in normal versus tumor tissue (log2 FC = −1.059, t-test p < 0.001).
This table shows molecular features associated with KLF3-AS1 in patient tissues and cancer cell lines. In patient samples, KLF3-AS1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, KLF3-AS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in NCI60_ALL.
