KLF3-AS1

Across TCGA pan-cancer cohorts, KLF3-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KLF3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where KLF3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types KLF3-AS1 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

UCEC, BRCA, and LIHC are the cancer types where KLF3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−1.059	<.001	6	view →
BRCA	Female	All	−1.005	<.001	6	view →
LIHC	All	All	+0.182	.002	6	view →
LUSC	Male	III,IV	−0.827	<.001	5	view →
KICH	All	All	−0.756	<.001	5	view →
HNSC	All	All	−0.205	.002	4	view →
CHOL	All	All	+0.840	<.001	3	view →
LUAD	All	II,III,IV	−0.350	.011	3	view →
STAD	Female	All	−0.615	.026	2	view →
THCA	All	All	−0.369	.015	2	view →
COAD	All	All	+0.183	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KLF3-AS1–UCEC

Open the UCEC breakdown →