KLF15

Across TCGA patient cohorts, KLF15 mutation is significantly associated with the RNA expression of many other genes, with 835 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF15-associated genes across cancer lineages are TUBGCP5, ATP5MC2P2, and RNU6-528P. Each is linked with KLF15 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF15-to-partner and partner-to-KLF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBGCP5 grouped by KLF15-low versus KLF15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF15→partner) and Y-score (partner→KLF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBGCP5 →	+0.440	+2.354	.003	.003	3	2
SKCM	ATP5MC2P2 →	+0.170	+3.818	.004	.002	3	2
LIHC	RNU6-528P →	+0.247	+5.902	<.001	.001	3	2
UCEC	PITPNB →	+0.407	+3.191	.006	.009	3	2
UCEC	POLR2A →	+0.763	+3.354	<.001	.005	3	2
UCEC	MRPS11 →	+0.494	+3.627	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 835 associations by consensus.

TUBGCP5 by KLF15 expression — UCEC

Explore this box plot interactively →