KLF15

Across TCGA pan-cancer cohorts, KLF15 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of KLF15’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLF15 RNA is repressed in tumor relative to normal tissue. In most cancer types KLF15 is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where KLF15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.457	<.001	12	view →
THCA	Male	III,IV	−2.142	<.001	10	view →
LUAD	Male	III,IV	−2.833	<.001	9	view →
LUSC	Female	II,III,IV	−2.637	<.001	9	view →
STAD	All	All	−1.740	<.001	9	view →
KIRP	All	III,IV	−1.788	<.001	8	view →
BLCA	All	All	−1.446	<.001	8	view →
KIRC	Male	All	−1.284	<.001	7	view →
BRCA	All	III,IV	−2.933	<.001	6	view →
UCEC	All	All	−1.700	<.001	4	view →
KICH	All	All	−1.571	<.001	4	view →
LIHC	Male	All	+0.872	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

KLF15–HNSC

Open the HNSC breakdown →