KIN

Across TCGA patient cohorts, KIN mutation is significantly associated with the RNA expression of many other genes, with 392 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIN-associated genes across cancer lineages are RPS29P2, MLX, and RPL23AP82. Each is linked with KIN in more than 1 cancer types. Because this analysis shows association rather than direction, both KIN-to-partner and partner-to-KIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P2 grouped by KIN-low versus KIN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIN→partner) and Y-score (partner→KIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS29P2 →	+0.266	+4.418	<.001	.006	3	2
UCEC	MLX →	+0.519	+3.633	.002	.001	3	2
UCEC	RPL23AP82 →	+0.388	+3.818	.008	<.001	3	2
UCEC	RNU6-598P →	+0.232	+2.782	<.001	.004	3	2
BLCA	MIR938 →	+0.546	+4.173	<.001	.001	3	2
BLCA	MAGEA7P →	+0.078	+3.593	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 392 associations by consensus.

RPS29P2 by KIN expression — LUAD

Explore this box plot interactively →