KIN

Across TCGA pan-cancer cohorts, KIN RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated KIN data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher KIN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KIN expression acts as an unfavorable survival marker, although some lineages such as LGG and BLCA show a favorable association.

LIHC, KIRP, and ACC are the cancer types where KIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	III,IV	0.445	0.748	<.001	80	view →
KIRP	DFS	Median	All	0.471	0.694	.001	78	view →
ACC	DFS	Median	All	0.331	0.822	<.001	77	view →
KIRC	DFS	Quartile	III,IV	0.525	0.860	.001	45	view →
LGG	OS	Median	All	0.939	0.849	<.001	35	view →
MESO	OS	Quartile	All	0.414	0.622	.006	34	view →
BLCA	OS	Tertile	All	0.667	0.541	.015	34	view →
BRCA	OS	Tertile	All	0.558	0.750	.001	34	view →
THYM	DFS	Quartile	All	0.929	0.553	.001	34	view →
CESC	DFS	Tertile	III,IV	0.554	0.940	<.001	32	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	25	view →
LUSC	OS	Tertile	III,IV	0.755	0.483	.007	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

KIN–LIHC (OS)

Open the LIHC breakdown →