KIF5A

Across TCGA patient cohorts, KIF5A protein abundance is significantly associated with the RNA expression of many other genes, with 5,983 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KIF5A-associated genes across cancer lineages are SMC4, MRPL3, and SLC39A8. Each is linked with KIF5A in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF5A-to-partner and partner-to-KIF5A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KIF5A versus SMC4 in LSCC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF5A→partner) and Y-score (partner→KIF5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC4 →	+0.792	+0.460	<.001	<.001	3	3
CCRCC	MRPL3 →	+0.553	+0.372	<.001	.003	3	3
GBM	SLC39A8 →	-1.091	-0.365	<.001	.001	3	3
LSCC	TOPBP1 →	+0.675	+0.420	<.001	<.001	3	3
LSCC	DNAJC19 →	+0.680	+0.407	<.001	<.001	3	3
LSCC	ECT2 →	+0.944	+0.432	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,983 associations by consensus.

KIF5A vs SMC4 — LSCC

Explore this scatter interactively →