KIF4A

Across TCGA patient cohorts, KIF4A mutation is significantly associated with the RNA expression of many other genes, with 6,318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF4A-associated genes across cancer lineages are IGHD5-12, MIR549A, and IGHD3-3. Each is linked with KIF4A in more than 4 cancer types. Because this analysis shows association rather than direction, both KIF4A-to-partner and partner-to-KIF4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5-12 grouped by KIF4A-low versus KIF4A-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF4A→partner) and Y-score (partner→KIF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	IGHD5-12 →	+1.742	+5.421	<.001	.005	3	5
BLCA	MIR549A →	+0.273	+4.562	<.001	.006	3	3
BRCA	IGHD3-3 →	+1.504	+3.028	<.001	.001	3	3
CESC	LETM1 →	+0.678	+3.219	<.001	.009	3	3
UCEC	FANCL →	+0.285	+2.158	.007	<.001	3	3
UCEC	PDCD2L →	+0.304	+1.445	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,318 associations by consensus.

IGHD5-12 by KIF4A expression — READ

Explore this box plot interactively →