KIF4A

Across TCGA pan-cancer cohorts, KIF4A RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated KIF4A data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KIF4A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF4A expression acts as an unfavorable survival marker, although some lineages such as SCLC and THYM show a favorable association.

KIRP, ACC, and MESO are the cancer types where KIF4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.770	0.931	<.001	167	view →
ACC	OS	Median	All	0.401	0.819	<.001	138	view →
MESO	OS	Median	All	0.362	0.723	<.001	123	view →
KIRC	DFS	Median	All	0.563	0.732	<.001	96	view →
KICH	OS	Median	III,IV	0.524	1.000	<.001	93	view →
LIHC	DFS	Median	All	0.455	0.625	<.001	90	view →
LUAD	OS	Tertile	All	0.591	0.780	<.001	76	view →
PAAD	OS	Tertile	All	0.453	0.718	<.001	62	view →
LGG	OS	Median	All	0.704	0.920	<.001	54	view →
SCLC	OS	Tertile	All	0.803	0.462	.003	43	view →
SARC	DFS	Median	All	0.419	0.610	<.001	36	view →
BRCA	OS	Median	II,III,IV	0.890	0.933	.007	35	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

KIF4A–KIRP (DFS)

Open the KIRP breakdown →