KIF4A

Across TCGA pan-cancer cohorts, KIF4A RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of KIF4A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIF4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIF4A is over-expressed in tumor.

HNSC, LUAD, and BLCA are the cancer types where KIF4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+2.302	<.001	12	view →
LUAD	Male	III,IV	+3.638	<.001	11	view →
BLCA	Male	III,IV	+3.385	<.001	11	view →
KIRP	All	IV	+2.447	<.001	11	view →
COAD	Male	All	+1.566	<.001	11	view →
KIRC	Male	IV	+1.537	<.001	11	view →
THCA	All	III,IV	+0.792	<.001	10	view →
LIHC	Male	II,III,IV	+2.260	<.001	9	view →
LUSC	Female	All	+3.819	<.001	8	view →
UCEC	All	III,IV	+3.657	<.001	8	view →
STAD	Female	All	+2.777	<.001	8	view →
BRCA	All	II,III,IV	+3.044	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

KIF4A–HNSC

Open the HNSC breakdown →