KIF4A

Across TCGA cell cohorts, KIF4A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,308 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KIF4A-associated GO terms across cancer lineages are Spindle elongation, Spindle midzone assembly, and Mitotic spindle midzone assembly. Each is linked with KIF4A in more than 19 cancer types. Because this analysis shows association rather than direction, both KIF4A-to-partner and partner-to-KIF4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by KIF4A-low versus KIF4A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF4A→partner) and Y-score (partner→KIF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Spindle elongation →	+0.302	+1.931	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Spindle midzone assembly →	+0.264	+1.710	<.001	<.001	3	20
OESOPHAGUS	Mitotic spindle midzone assembly →	+0.260	+1.206	<.001	<.001	3	20
OESOPHAGUS	Mitotic spindle elongation →	+0.260	+1.206	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Nuclear division →	+0.103	+1.441	<.001	<.001	3	20
BLOOD_Myeloma	Positive regulation of cell cycle →	+0.083	+1.375	<.001	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,308 associations by consensus.

Spindle elongation by KIF4A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →