KIF4A

Across TCGA cell cohorts, KIF4A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF4A-associated genes across cancer lineages are S100G, DMRTB1, and MYH4. Each is linked with KIF4A in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF4A-to-partner and partner-to-KIF4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100G grouped by KIF4A-low versus KIF4A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF4A→partner) and Y-score (partner→KIF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	S100G →	+0.135	+4.321	<.001	.009	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
BLOOD_Leukemia	MYH4 →	+0.003	+4.384	<.001	.006	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
LARGE_INTESTINE	ACER1 →	+0.092	+3.823	.001	.006	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

S100G by KIF4A expression — CNS

Explore this box plot interactively →