KIF3C

Across TCGA patient cohorts, KIF3C mutation is significantly associated with the RNA expression of many other genes, with 3,997 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF3C-associated genes across cancer lineages are COPS3, OR2AG1, and PSMC3IP. Each is linked with KIF3C in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF3C-to-partner and partner-to-KIF3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS3 grouped by KIF3C-low versus KIF3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF3C→partner) and Y-score (partner→KIF3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS3 →	+0.560	+2.536	<.001	<.001	3	4
BRCA	OR2AG1 →	+0.105	+8.044	<.001	<.001	3	3
COAD	PSMC3IP →	+0.667	+3.200	<.001	.009	3	3
UCEC	FANCG →	+0.549	+3.098	<.001	<.001	3	3
UCEC	MAD2L1 →	+0.771	+1.968	<.001	<.001	3	3
UCEC	PRDX3 →	+0.427	+2.288	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,997 associations by consensus.

COPS3 by KIF3C expression — UCEC

Explore this box plot interactively →