KIF3C

Across TCGA pan-cancer cohorts, KIF3C RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KIF3C data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher KIF3C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KIF3C expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

MESO, BLCA, and KIRP are the cancer types where KIF3C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.276	0.492	<.001	117	view →
BLCA	DFS	Tertile	All	0.166	0.584	<.001	63	view →
KIRP	OS	Tertile	All	0.525	0.957	.003	44	view →
LIHC	OS	Median	All	0.712	0.838	<.001	44	view →
LGG	DFS	Median	All	0.798	0.668	<.001	42	view →
UCEC	OS	Tertile	All	0.874	0.960	.001	42	view →
LUSC	DFS	Tertile	III,IV	0.237	0.961	<.001	41	view →
KIRC	DFS	Median	All	0.748	0.516	.001	40	view →
HNSC	OS	Median	All	0.586	0.821	<.001	40	view →
ACC	DFS	Tertile	All	0.283	0.699	.001	39	view →
SCLC	OS	Quartile	II,III,IV	0.752	0.295	.001	35	view →
STAD	OS	Median	II,III,IV	0.486	0.637	.008	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KIF3C–MESO (OS)

Open the MESO breakdown →