KIF3C

Across TCGA pan-cancer cohorts, KIF3C RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KIF3C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIF3C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIF3C is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where KIF3C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF3C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.296	<.001	12	view →
BLCA	All	All	+1.297	<.001	11	view →
LUAD	Male	III,IV	+2.145	<.001	10	view →
LUSC	Female	II,III,IV	+1.927	<.001	7	view →
KIRP	Female	All	+1.430	.004	7	view →
THCA	All	All	−0.511	<.001	7	view →
KIRC	All	All	+0.499	<.001	6	view →
BRCA	All	II,III,IV	+0.319	.002	6	view →
CHOL	All	All	+3.508	<.001	5	view →
KICH	Female	All	−0.902	<.001	4	view →
COAD	All	All	+0.497	.003	4	view →
LIHC	All	All	+0.433	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KIF3C–HNSC

Open the HNSC breakdown →