KIF3C

Across TCGA cell cohorts, KIF3C mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF3C-associated genes across cancer lineages are ACSM6, ZFP2, and FOXS1. Each is linked with KIF3C in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF3C-to-partner and partner-to-KIF3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by KIF3C-low versus KIF3C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF3C→partner) and Y-score (partner→KIF3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.019	+3.321	<.001	<.001	3	2
LARGE_INTESTINE	ZFP2 →	+0.423	+3.299	<.001	.004	3	2
BLOOD_Leukemia	FOXS1 →	+0.053	+3.814	.001	.002	3	2
LARGE_INTESTINE	SLC25A1 →	+0.662	+3.212	.007	.006	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.650	+3.212	.001	.006	3	1
LARGE_INTESTINE	DESI1 →	+0.518	+3.299	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

ACSM6 by KIF3C expression — LARGE_INTESTINE

Explore this box plot interactively →