KIF2A

Across TCGA patient cohorts, KIF2A mutation is significantly associated with the RNA expression of many other genes, with 2,360 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF2A-associated genes across cancer lineages are RPS12P15, KRT128P, and LINC00313. Each is linked with KIF2A in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF2A-to-partner and partner-to-KIF2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS12P15 grouped by KIF2A-low versus KIF2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF2A→partner) and Y-score (partner→KIF2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS12P15 →	+0.197	+5.278	<.001	<.001	3	3
BRCA	KRT128P →	+0.041	+4.215	.001	.009	3	2
SKCM	LINC00313 →	+0.092	+3.854	.001	.003	3	2
LUSC	SNORD116-10 →	+0.209	+5.102	.001	.002	3	2
SKCM	RNU1-31P →	+0.222	+4.098	<.001	.001	3	2
SKCM	LINC01280 →	+0.054	+3.099	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,360 associations by consensus.

RPS12P15 by KIF2A expression — COAD

Explore this box plot interactively →