KIF2A

Across TCGA pan-cancer cohorts, KIF2A RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated KIF2A data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher KIF2A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KIF2A expression acts as an unfavorable survival marker, although some lineages such as COAD and READ show a favorable association.

MESO, LIHC, and ACC are the cancer types where KIF2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.309	0.623	.001	74	view →
LIHC	OS	Median	All	0.609	0.771	<.001	63	view →
ACC	DFS	Tertile	All	0.496	0.855	<.001	55	view →
KICH	OS	Median	II,III,IV	0.629	0.959	.003	46	view →
COAD	OS	Median	II,III,IV	0.882	0.674	.001	39	view →
READ	DFS	Quartile	III,IV	1.000	0.607	.015	31	view →
LGG	DFS	Median	All	0.528	0.295	<.001	29	view →
KIRC	DFS	Tertile	III,IV	0.756	0.493	.014	26	view →
LUSC	DFS	Quartile	All	0.261	0.498	.005	25	view →
HNSC	DFS	Quartile	All	0.828	0.640	.001	24	view →
SKCM	DFS	Tertile	All	0.803	0.657	.002	19	view →
THYM	DFS	Quartile	All	1.000	0.854	.010	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

KIF2A–MESO (OS)

Open the MESO breakdown →