KIF1C

Across TCGA patient cohorts, KIF1C mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF1C-associated genes across cancer lineages are C-Raf, beta-Catenin, and INPP4B. Each is linked with KIF1C in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF1C-to-partner and partner-to-KIF1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by KIF1C-low versus KIF1C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF1C→partner) and Y-score (partner→KIF1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.179	+2.815	.025	.036	3	3
STAD	beta-Catenin →	+0.838	+3.169	.019	.019	3	2
UCEC	INPP4B →	-0.220	-1.678	.042	.019	3	2
UCEC	p90 RSK →	+0.126	+1.594	.049	.021	3	2
UCEC	ASNS →	+0.441	+1.765	<.001	.013	3	2
UCEC	ATM →	-0.437	-1.874	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

C-Raf by KIF1C expression — COAD

Explore this box plot interactively →