KIF1C

Across TCGA pan-cancer cohorts, KIF1C RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated KIF1C data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KIF1C RNA is associated with better overall survival. In most high-consensus cancer types, elevated KIF1C expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

KIRP, KICH, and KIRC are the cancer types where KIF1C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.780	0.598	<.001	99	view →
KICH	OS	Median	All	0.653	1.000	.001	62	view →
KIRC	OS	Median	All	0.730	0.550	<.001	52	view →
UCEC	DFS	Tertile	III,IV	0.912	0.733	<.001	44	view →
BLCA	OS	Tertile	All	0.319	0.523	.004	43	view →
ACC	DFS	Tertile	All	0.125	0.643	<.001	43	view →
SKCM	OS	Median	All	0.273	0.403	.002	19	view →
LUSC	DFS	Quartile	III,IV	0.407	0.935	.014	19	view →
UVM	DFS	Quartile	All	0.962	0.635	.007	14	view →
SCLC	DFS	Tertile	IV	0.137	0.534	.024	12	view →
UCS	DFS	Tertile	IV	0.956	0.510	.024	12	view →
CESC	OS	Median	II,III,IV	0.406	0.755	.025	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

KIF1C–KIRP (OS)

Open the KIRP breakdown →