KIF1C

Across TCGA pan-cancer cohorts, KIF1C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KIF1C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KIF1C RNA is repressed in tumor relative to normal tissue. In most cancer types KIF1C is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where KIF1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.006	<.001	11	view →
KIRC	Male	II,III,IV	−0.989	<.001	11	view →
LUAD	Female	All	−1.438	<.001	9	view →
HNSC	Male	IV	−1.155	<.001	8	view →
KICH	All	All	−0.877	<.001	7	view →
LUSC	Female	All	−1.462	<.001	6	view →
BRCA	All	III,IV	−1.070	<.001	6	view →
LIHC	Female	II,III,IV	+0.971	<.001	6	view →
CHOL	All	All	+1.488	<.001	5	view →
BLCA	All	III,IV	−0.626	.018	5	view →
THCA	All	II,III,IV	−0.311	.009	5	view →
READ	Female	All	−1.098	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KIF1C–COAD

Open the COAD breakdown →