KIF1C

Across TCGA cell cohorts, KIF1C mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF1C-associated genes across cancer lineages are ZNF831, PGK2, and TTLL2. Each is linked with KIF1C in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF1C-to-partner and partner-to-KIF1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by KIF1C-low versus KIF1C-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF1C→partner) and Y-score (partner→KIF1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF831 →	+0.183	+4.467	<.001	.004	3	2
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
BLOOD_Leukemia	TTLL2 →	+0.308	+3.540	<.001	.005	3	1
BLOOD_Leukemia	PRB2 →	+0.110	+2.906	.001	.009	3	1
BLOOD_Leukemia	PAX1 →	+0.040	+3.890	<.001	<.001	3	1
BLOOD_Leukemia	CYP39A1 →	+0.208	+3.091	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

ZNF831 by KIF1C expression — SKIN

Explore this box plot interactively →