KIF14

Across TCGA patient cohorts, KIF14 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF14-associated genes across cancer lineages are PDCD4, TFRC, and ATM. Each is linked with KIF14 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF14-to-partner and partner-to-KIF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by KIF14-low versus KIF14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF14→partner) and Y-score (partner→KIF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.457	-2.321	<.001	<.001	3	3
SKCM	TFRC →	+0.732	+3.169	.008	.018	3	3
UCEC	ATM →	-0.502	-2.649	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.323	+1.171	.043	.031	3	3
UCEC	4E-BP1 →	+0.260	+2.321	<.001	<.001	3	3
COAD	Bad_pS112 →	-0.202	-3.313	.028	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

PDCD4 by KIF14 expression — UCEC

Explore this box plot interactively →