KIF14

Across TCGA pan-cancer cohorts, KIF14 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of KIF14’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIF14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIF14 is over-expressed in tumor.

HNSC, BLCA, and KIRP are the cancer types where KIF14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+2.145	<.001	12	view →
BLCA	Male	III,IV	+2.778	<.001	11	view →
KIRP	All	III,IV	+1.223	<.001	11	view →
KIRC	Male	IV	+0.865	<.001	11	view →
STAD	Female	All	+2.185	<.001	10	view →
COAD	Male	All	+1.277	<.001	10	view →
LUAD	Male	III,IV	+2.538	<.001	9	view →
LUSC	Male	II,III,IV	+2.955	<.001	8	view →
LIHC	Male	All	+1.256	<.001	8	view →
UCEC	All	III,IV	+2.373	<.001	6	view →
BRCA	All	III,IV	+2.119	<.001	6	view →
CHOL	Male	All	+2.511	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

KIF14–HNSC

Open the HNSC breakdown →