KIF14

Across TCGA pan-cancer cohorts, KIF14 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated KIF14 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KIF14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF14 expression acts as an unfavorable survival marker, although some lineages such as GBM and THYM show a favorable association.

ACC, KIRP, and MESO are the cancer types where KIF14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.315	0.837	<.001	143	view →
KIRP	DFS	Median	All	0.761	0.939	<.001	143	view →
MESO	OS	Median	All	0.354	0.731	<.001	141	view →
UVM	DFS	Quartile	II,III,IV	0.252	0.857	<.001	96	view →
LUAD	OS	Median	All	0.287	0.435	<.001	93	view →
KIRC	DFS	Quartile	All	0.512	0.758	<.001	88	view →
KICH	DFS	Quartile	II,III,IV	0.447	1.000	.001	79	view →
LIHC	OS	Median	All	0.706	0.845	<.001	76	view →
PAAD	OS	Median	All	0.279	0.533	<.001	54	view →
LGG	OS	Median	All	0.711	0.912	<.001	54	view →
THCA	DFS	Median	III,IV	0.553	0.846	.003	35	view →
CESC	DFS	Median	All	0.768	0.875	.002	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

KIF14–ACC (DFS)

Open the ACC breakdown →